New Preprint alert! Our latest published results describe a new method for integrating catalytic functionality into 3D-printed tissue constructs.  Join me in diving into a short overview of this research project combining chemistry with biomaterials and medicine.

“Enzyme Bioink for the 3D Printing of Biocatalytic Materials”
L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich
bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

One key obstacle for creating fully functional tissues and organs is replicating an active biochemical environment. This is a major hurdle in #TissueEngineering and #WoundHealing
The team led by Luca Altevogt and Rakib Sheikh tackled the challenge by combining #enzymes, nature’s molecular machines, with #biomaterials that are required as scaffold constructs to make new #tissue.
Our “secret” ingredient? The enzyme horseradish peroxidase! By covalently attaching it to a traditional gelatin scaffold that is widely used, we’ve unlocked stable and long-lasting bioactivity in our #hydrogel bioinks.
Tests confirm our enzyme-retaining scaffolds are cytocompatible, ensuring non-toxicity to cells. This opens doors to safer and more effective tissue fabrication methods.
We believe our findings represent an important contribution towards the #biofabrication of functional tissues. Stay tuned for more updates on our journey 🧪 🚀
Massive thanks also to everyone else involved in the team; Thomas Molley, Joel Yong, Kang Liang, Patrick Spicer and Kristopher Kilian

#UNSW #UNSWEngineering #WichLab #SciComm #OpenAccess #Research #biotech #innovation #tissueengineering #biofabrication #3DBioprinting #enzymes #biopolymers

 

Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699) Enzyme Bioink for the 3D Printing of Biocatalytic Materials L. A. Altevogt, R. H. Sheikh, T. G. Molley, J. Yong, K. Liang, P. Spicer, K. A. Kilian, P. R. Wich bioRxiv, 2024, 2024.02.04.577699. (DOI: https://doi.org/10.1101/2024.02.04.577699)

 

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