Great work Benjamin and Ira, congrats!!
The paper describes the synthesis of an acid-degradable micellar nanoparticle system. It is the first reported fully polysaccharide-based amphiphile that is degradable and forms nanoparticles.
“Amphiphilic Polysaccharide Block Copolymers for pH-responsive Micellar Nanoparticles”
B. Breitenbach, I. Schmid, P. R. Wich
Biomacromolecules 2017, ASAP. (DOI: 10.1021/acs.biomac.7b00771)
A full polysaccharide amphiphilic block copolymer was prepared from end group-functionalized dextrans using copper mediated azide-alkyne click chemistry. Sufficient modification of the reducing end in both blocks was achieved by microwave-enhanced reductive amination in a borate-buffer/methanol solvent system. The combination of a hydrophilic dextran block with a hydrophobic acetalated dextran block results in an amphiphilic structure that turns water-soluble upon acid treatment. The material has a low CMC and self-assembles in water to spherical micellar nanoparticles. The formed nanoparticles have a narrow size distribution below 70 nm in diameter and disassemble in slightly acidic conditions. The amphiphilic polysaccharide system shows low toxicity and can stabilize the hydrophobic model drug curcumin in aqueous solutions over extended time periods.