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“Development of Novel Peptide-based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs)”
S. Previti, R. Ettari, S. Cosconati, G. Amendola, K. Chouchene, A. Wagner, U. A. Hellmich, K. Ulrich, R. L. Krauth-Siegel, I. Schmid, P. R. Wich, T. Schirmeister, J. Gut, P. J. Rosenthal, S. Grasso, M. Zappalà,
J. Med. Chem. 2017, just accepted. (DOI: 10.1021/acs.jmedchem.7b00405)

The paper describes the synthesis of an acid-degradable micellar nanoparticle system. It is the first reported fully polysaccharide-based amphiphile that is degradable and forms nanoparticles.
B. Breitenbach, I. Schmid, P. R. Wich, Biomacromolecules 2017, ASAP.

The master study course “Biomedical Chemistry” represents a unique link between the traditional fields of chemistry, pharmacy, biology, and medicine. To ensure that the knowledge acquired during the studies can also be applied practically, students learn special techinques in practical laboratory courses and modules. For this, the “Fonds der Chemischen Industrie” (FCI) supports the purchase of an HPLC instrument with 14,000 Euros.

Welcome and good luck with your experiments!

Lydia’s poster on protein nanoparticles was selected as candidate for the PMSE Best Poster Award at the ACS conference in San Francisco – Congratulations!

Matthias successfully defended his PhD work! Congratulations, great job! We wish you all the best for your upcoming Postdoc!

What do you think about our “trippy” design? :)

You can find our corresponding article here:
“Nanoparticle Assembly of Surface-Modified Proteins”
M. Fach, L. Radi, P. R. Wich, J. Am. Chem. Soc., 2016, 138 (45), 14820–14823.
http://pubs.acs.org/doi/abs/10.1021/jacs.6b06243

“Dextran-based therapeutic nanoparticles for hepatic drug delivery” were developed in a fruitful cooperation with the University Medical Center in Mainz

Congrats Lydia and Matthias on your paper in MedChemCom! “Methods of Protein Surface PEGylation under Structure Preservation for the Emulsion-based Formation of Stable Nanoparticles”

For this years summer group outing we parodied Germany´s favorite sport and played a round of “Fussball-Golf”. Apart from some exceptions, we all realized that soccer is definitly not our biggest strength (neither golf). But we definitly had our fun! (more pictures after the click)