Travelling Through the Blood Vessel Network of a Tumour

This fascinating depiction of the vascular network of a tumour is part of a wonderful exhibition of beautiful and creative microscope images by female-identifying researchers @UNSW
https://www.edi.unsw.edu.au/the-illuminators

This is only one of many exciting events and activities for this weeks #UNSW Diversity Fest 2021
https://www.edi.unsw.edu.au/diversityfest

Picture/Video (Florence Tomasetig): “Travelling Through the Blood Vessel Network of a Tumour”
The picture shows the complex vascular architecture of a tumour. To capture the images the tumour was made transparent to allow light to penetrate through it. The blood vessels (red) and type of immune cell (green) were modified to express a protein that emits light when excited by a laser. The immune cells seem to be floating inside the tumour but they are actually squished between the transparent tumour cells. The 3D animation was created from tens of thousands of 2D images stitched and stacked together to reconstruct the 3D architecture of a tumour. 

Huge thanks to all the authors involved in this study, in particular Florence Tomasetig, Dr. Shweta Tikoo and Rohit Jain and Prof. Wolfgang Weninger.
“Amelanotic B16-F10 Melanoma Compatible with Advanced Three-Dimensional Imaging Modalities”
Journal of Investigative Dermatology (2021) 141, 2090e2094; doi:10.1016/j.jid.2021.01.025
Direct link to the article: https://doi.org/10.1016/j.jid.2021.01.025

 

 

Reprinted from Journal of Investigative Dermatology, Vol 141, Tikoo S et al., Amelanotic B16-F10 Melanoma Compatible with Advanced Three-Dimensional Imaging Modalities, P2090-2094, Copyright (2021), with permission from Elsevier. Home Page: Journal of Investigative Dermatology (jidonline.org)