Journals/Books

Nanomedicine Bamberger Wich Wichlab Dextran Nanoparticles“Dextran-based Therapeutic Nanoparticles for Hepatic Drug Delivery”
F. Foerster, D. Bamberger, J. Schupp, M. Weilbächer, L. Kaps, S. Strobl, L. Radi, M. Diken, D. Strand, A. Tuettenberg, P. R. Wich, D. Schuppan
Nanomedicine 2016, 11 (20), 2663–2677. (DOI: 10.2217/nnm-2016-0156)

 

 

 

MedChemComm Radi Fach Wich

“Methods of Protein Surface PEGylation under Structure Preservation for the Emulsion-based Formation of Stable Nanoparticles”
L. Radi, M. Fach, M. Montigny, E. Berger-Nicoletti, W. Tremel, P. R. Wich
Med. Chem. Commun. 2016, 7, 1738–1744 (DOI: 10.1039/C5MD00475F)
(This article is part of themed collection: New Talent: Europe)

 

 

“Nanoparticle Assembly of Surface-Modified Proteins” JACS Wich Fach Radi
M. Fach, L. Radi, P. R. Wich
J. Am. Chem. Soc., 2016, 138 (45), 14820–14823 (DOI: 10.1021/jacs.6b06243)

 

 

 

“Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors”JACS Schirmeister Engels Wich
T. Schirmeister, J. Kesselring, S. Jung, T. H. Schneider, A. Weickert, J. Becker, W. Lee, D. Bamberger, P. R. Wich, U. Distler, S. Tenzer, P. Johé, U. A. Hellmich, B. Engels
J. Am. Chem. Soc., 2016, 138 (27), 8332–8335. (DOI: 10.1021/jacs.6b03052)

 

 

 

“Biopolymere – Baukasten der Natur” Biopolymere - Biopolymers Wichlab
P. R. Wich
Nachrichten aus der Chemie, 2015, 63 (2), 128–138. (DOI: 10.1002/nadc.201590046) (pdf download)

 

 

 

“Organische Chemie – Beyer/Walter”2015 Beyer Walter - Organische Chemie Lehrbuch - Schirmeister Schmuck Wich T. Schirmeister, C. Schmuck, P. R. Wich
S. Hirzel Verlag 2015. (read more in our blog post) (Announcement: Ein Klassiker feiert Jubiläum)
(fundamentally revised edition – restructuring includes 38 chapters, complete coverage of all fields of organic chemistry; content update and revision of all structural formulas and diagrams; 1176 pages, 25th edition)

 

 

 

publications-2013-Jiang-OrgBiomolChem
“A New Approach to Inhibit Human β-Tryptase by Protein Surface Binding of Four-Armed Peptide Ligands with Two Different Sets of Arms”
Q.-Q. Jiang, L. Bartsch, W. Sicking, P. R. Wich, D. Heider,D. Hoffmann, C. Schmuck
Org. Biomol. Chem. 201311, 1631–1639. (DOI: 10.1039/C3OB27302D). (selected as Organic & Biomolecular Chemistry HOT Article)

 

 

publications-17“Aerosolized Antimicrobial Agents Based on Degradable Dextran Nanoparticles Loaded with Silver Carbene Complexes”
C. Ornelas-Megiatto, P. Shah, P.R. Wich, J. Cohen, J. Tagaev, J. Smolen, B. Wright, M. Panzner, W. Youngs, J. M. J. Fréchet, C. Cannon
Mol. Pharmaceutics. 2012, 9 (11), 3012–3022. (DOI: 10.1021/mp3004379)

 

 

 

publications-16“Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA”
L. Cui, J. L. Cohen, C. K. Chu, P. R. Wich, P. H. Kierstead, J. M. J. Fréchet
J. Am. Chem. Soc. 2012134 (38), 15840–15848. (DOI: 10.1021/ja305552u)

 

 

 

publications-15“Polyphosphonium Polymers for siRNA Delivery: An Efficient and Non-Toxic Alternative to Polyammonium Carriers”
C. Ornelas-Megiatto, P. R. Wich, J. M. J. Fréchet
J. Am. Chem. Soc. 2012134, 1902–1905. (DOI: 10.1021/ja207366k)

 

 

 

publications-14“Degradable Dextran Particles for Gene Delivery Applications”
P. R. Wich, J. M. J. Fréchet
Aust. J. Chem. 20121, 15-19. (DOI: 10.1071/CH11370)

 

 

 

Surface Recognition and Inhibition of β-Tryptase by Tetravalent Peptide Ligands“Surface Recognition and Inhibition of β-Tryptase by Tetravalent Peptide Ligands”
P. R. Wich, C. Schmuck
Peptide Science 2010: Proceedings of the Fifth International Peptide Symposium, Kyoto, Japan, 04.-09. Dec 2010, (Ed.: N. Fujii, Y. Kiso), The Japanese Peptide Society,2011, p 59.

 

 

publications-12“Acid-Degradable Cationic Dextran Particles for the Delivery of siRNA Therapeutics”
J. L. Cohen, S. Schubert, P. R. Wich, L. Cui, J. A. Cohen, J. L. Mynar, and J. M. J. Fréchet
Bioconj. Chem. 201122, 1056–1065. (DOI: 10.1021/bc100542r)

 

 

 

publications-11“Reversible and Non-Competitive Inhibition of β-Tryptase by Tetravalent Peptide Ligands Identified from a Combinatorial Split-Mix-Library”
P. R. Wich, C. Schmuck
Angew. Chem. Int. Ed. 201049, 4113–4116. (DOI: 10.1002/anie.200907221)

 

 

publications-10“Site-specific pKa determination of the carboxylate-binding subunit in artificial peptide receptors”
S. Niebling, S. K. Srivastava, C. Herrmann, P. R. Wich, C. Schmuck, S. Schlücke
Chem. Commun. 201046, 2133–2135. (DOI: 10.1039/B926514G)

 

 

 

publications-09“Characterization of guanidiniocarbonyl pyrroles in water by pH-dependent UV Raman spectroscopy and component analysis”
S. K. Srivastava, S. Niebling, B. Küstner, P. R. Wich, C. Schmuck, S. Schlücker
Phys. Chem. Chem. Phys. 200810, 6770–6775. (DOI: 10.1039/b810908g)

 

 

 

publications-08“A Facile and Efficient Multi-Gram Synthesis of N-Protected 5-(Guanidinocarbonyl)-1H-pyrrole-2-carboxylic Acids”
C. Schmuck, V. Bickert, M. Merschky, L. Geiger, D. Rupprecht, J. Dudaczek, P. Wich, T. Rehm, U. Machon
Eur. J. Org. Chem. 20082, 324–329. (DOI: 10.1002/ejoc.200700756)

 

 

publications-07“UV resonance Raman spectroscopic monitoring of supramolecular complex formation: peptide recognition in aqueous solution”
B. Küstner, C. Schmuck, P. Wich, C. Jehn, S. K. Srivastava, S. Schlücker
Phys. Chem. Chem. Phys. 2007,32, 4598–4603. (DOI: 10.1039/b709142g)

 

 

 

publications-06“The Development of Artificial Receptors for Small Peptides Using Combinatorial Approaches”
C. Schmuck, P. Wich
Topics Curr. Chem. 2007277, 3–30. (Creative Chemical Sensor Systems, Volume Editor, Th. Schrader) (DOI: 10.1007/128_2007_111)

 

 

 

publications-05“Direct and Label-Free Detection of Solid-Phase-Bound Compounds by Using Surface-Enhanced Raman Scattering Microspectroscopy”
C. Schmuck, P. Wich, B. Küstner, W. Kiefer and S. Schlücker
Angew. Chem. Int. Ed. 200746, 4786–4789. (DOI: 10.1002/anie.200605190)

 

 

 

publications-04“Atropodiastereoselective Cleavage of Configurationally Unstable Biaryl Lactones with Amino Acid Esters”
G. Bringmann, H. Scharl, K. Maksimenka, K. Radacki, H. Braunschweig, P. Wich, C. Schmuck
Eur. J. Org. Chem. 2006, 4349–4361. (DOI: 10.1002/ejoc.200600311)

 

 

 

publications-03“Combinatorial receptor finding – small and focused vs. large and random libraries”
C. Schmuck, P. Wich
New J. Chem.200630, 1377–1385. (DOI: 10.1039/b605731b)

 

 

 

publications-02“Sequence-Dependent Stereoselectivity in the Binding of Tetrapeptides in Water by a Flexible Artificial Receptor”
C. Schmuck, P. Wich
Angew. Chem. Int. Ed. 200645, 4277–4281. (DOI: 10.1002/anie.200601046)  (Angew. Chem. 2006, 118, 4383–4387. DOI: 10.1002/ange.200601046)

 

 

“Synthesis and Reactivity of an Enantiomerically Pure N-Methyl-2-silyl Substituted Pyrrolidine”
K. Strohfeldt, T. Seibel, P. Wich, C. Strohmann
Organosilicon Chemistry VI, (Hrsg.: N. Auner, J. Weis), Wiley-VCH, Weinheim, 2005. (DOI: 10.1002/9783527618224) (Publisher Link)

 

Oral Presentations

25. “Biopolymers as Multifunctional Materials for Nanoparticulate Drug Delivery” P. R. Wich, DPhG-Jahrestagung 2016, München, Germany, 05.-07. Oct 2016.

24. “Biopolymer-based Nanoparticles: Dynamic Materials for Drug Delivery” P. R. Wich, Warwick Polymer Conference 2016, Warwick, UK, 11.–14. Jul 2016.

23. “Biopolymer-based Nanoparticles: Dynamic Materials for Drug Delivery” P. R. Wich, Global Forum on Advanced Materials and Technologies for Sustainable Development (GFMAT 2016), Toronto, Canada, 26. Jun – 01. Jul 2016.

22. “Protein-based Nanoparticles by Lipophilic Surface Modification of Lysozyme” P. R. Wich, Chemiedozententagung, Heidelberg, Germany, 21.–23. Mar 2016.

21. “Biopolymers as Dynamic Materials for Nanoparticulate Drug Delivery” P. R. Wich, 24. Nachwuchswissenschaftler-Symposium Bioorganische Chemie, Hamburg, Germany, 23.–25. Sep 2015.

20. “Acid-Degradable Polysaccharide Nanoparticles for the Delivery of Biotherapeutics” P. R. Wich, 6th European Conference Chemistry in the Life Sciences (ECCLS), Lisbon, Portugal, 12. Jun 2015.

19. “Biopolymers as Versatile Materials for Molecular Recognition and Drug Delivery” P. R. Wich, TU Braunschweig, GDCh Colloqium, Braunschweig, Germany, 08. Jun 2015.

18. “Supramolecular and Nanoparticulate Biopolymers for Therapeutic Applications” P. R. Wich, Lehrstuhl für Funktionswerkstoffe FMZ-LCTM Institutskolloqium, Würzburg, Germany, 06. May 2015.

17. “Biopolymers for Supramolecular Recognition and Nanoparticulate Drug Delivery” P. R. Wich, Frauenhofer ICT-IMM Institutskolloquium, Mainz, Germany, 13. Nov 2014.

16. “Supramolecular Recognition of Peptides and Proteins – An Attractive Tale” P. R. Wich, Reaxys Inspiring Chemistry Conference 2014, Grindelwald, Switzerland, 21.–24. Sep 2014.

15. “Dynamic Polysaccharide-based Carrier Systems for the Delivery of Biotherapeutics” P. R. Wich, 26th European Conference on Biomaterials, Liverpool, UK,  31. Aug. – 3. Sep 2014.

14. “Playing with Nature’s Toolkit” P. R. Wich, From Graduation to Innovation (GDCh/REAXYS event), Chemnitz, Germany, 24. Jun 2014.

13. “Supramolecular and Nanoparticulate Biopolymers for Therapeutic Applications” P. R. Wich, Frontiers in Medicinal Chemistry, Tübingen, Germany, 19. Mar 2014.

12. “Multifunctional Polysaccharide Nanoparticles with Tunable Degradability” P. R. Wich, SFB 1066 Seminar, Mainz, Germany, 27. Jan 2014.

11. “ Polymeric Particles as Multifunctional Delivery Systems for Biotherapeutics” P. R. Wich, Reaxys Inspiring Chemistry Conference 2013, Grindelwald, Switzerland, 22.–24. Sep 2013.

10. “Breaking the Walls of Protein Manipulation” P. R. Wich, Falling Walls Lab, Berlin, Germany, 8. Nov 2012.

9. “Acid-Degradable Dextran Particles for the Delivery of Biotherapeutics” P. R. Wich, DPhG-Jahrestagung 2012, Greifswald, Germany, 11.–13. Oct 2012.

8. “Dextran Based Particle Systems as Multifunctional Delivery Vehicles” P. R. Wich, J. M. J. Fréchet, 2nd International NanoMedicine Conference, Sydney, Australia,14.-16. Jul 2011.

7. “Surface Recognition and Inhibition of β-Tryptase by Tetravalent Peptide Ligands” P. R. Wich, C. Schmuck, 5th International Peptide Symposium, Kyoto, Japan, 04.-09. Dec 2010.

6. “Polymeric Particle Systems for the Delivery of Biotherapeutics” (invited plenary talk) P. R. Wich, J. M. J. Fréchet, ZING Polymer Chemistry Conference, Puerto Morelos, Mexico, 19.-22. Nov 2010.

5. “Acetal-modified Dextran Particles for siRNA Delivery” P. R. Wich, J. L. Cohen, S. Hornig, J. A. Cohen, J. M. J. Fréchet, 3rd EuCheMS Chemistry Congress, Nürnberg, Germany, 29. Aug – 02. Sep 2010.

4. “Artificial Oligopeptides as a Versatile Toolkit for Molecular Recognition Events – New Insights into Multivalency Effects, Protein Recognition and Enzyme Inhibition” P. R. Wich, oral presentation, 11th JCF-Frühjahrssymposium (JCF Spring Symposium), Essen, Germany, 11.-14. Mar 2009.

3. “Molecular recognition by one-armed artificial receptors in water – New insights from combinatorial methods as an ideal tool to identify peptide binders” P. Wich, oral presentation, Second Joint Ph.D. Students Meeting SFB 544/630, New Trends in Infectious Disease Research, Heidelberg, Germany, 23.-25. Nov 2006.

2. “Small and focused combinatorial libraries as a perfect tool to identify peptide binders” P. Wich, oral presentation, Intensive Course Medicinal Chemistry 2006, HoChiMinh-City, Vietnam, 02. Nov 2006.

1. “Combinatorial libraries as a tool to identify peptide binders: New insights into substrate- and sequence-selectivity” P. Wich, oral presentation, SFB 630-Colloquium, Würzburg, Germany, 17. Jul 2005.

Miscellaneous

Wichlab Peter Wich covers

VIII. “Degradable Dextran Particles for Gene Delivery Applications” P. R. Wich, J. M. J. Fréchet, Cover Picture, Aust. J. Chem. 2012, 1, 15-19.

VII. “Multifunctional Oligopeptides as an Artificial Toolkit for Molecular Recognition Events” P. R. Wich, PhD Thesis, 2009, Würzburg (Germany).

VI. “Characterization of guanidiniocarbonyl pyrroles in water by pH-dependent UV Raman spectroscopy and component analysis” S. K. Srivastava, S. Niebling, B. Küstner, P. R. Wich, C. Schmuck, S. Schlücker, Inside Cover Picture, Phys. Chem. Chem. Phys. 2008, 10, 6730.

V. “Combinatorial receptor finding – small and focused vs. large and random libraries” C. Schmuck, P. Wich, Cover Picture, New J. Chem. 2006, 30, 1349.

IV. “Atropodiastereoselective cleavage of configurationally unstable biaryl lactones with amino acid esters” G. Bringmann, H. Scharl, K. Maksimenka, K. Radacki, H. Braunschweig, P. Wich, C. Schmuck, Cover Picture, Eur. J. Org. Chem. 2006, 19, 4301.

III. “Die strategische Entwicklung der ALTANA Gruppe mit dem Beispiel der Aufspaltung in ALTANA Pharma und ALTANA Chemie” P. Wich, Final Thesis for degree: Certified Project Manager of Business Chemistry (GDCh), 2006, Würzburg (Germany).

II. “Substratselektivität künstlicher Peptidrezeptoren – Synthese und Screening einer kombinatorischen Tetrapeptidbibliothek” P. Wich, Diploma Thesis, 2005, Würzburg (Germany).

I. Author of monthly published column “World Wide Web – Tips” in Journal of the German Chemistry Society (GDCh) “Nachrichten der Chemie” (Blaue Blätter), (Dec 2002 – Dec 2005).

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