PROJECTS OVERVIEW

METHODS
Biopolymer Scaffolds
We modify natural biopolymers (sugars, peptides, proteins) to optimize their properties beyond the original functions.
Chemical Modification
The extensive toolkit of bioorganic chemistry provides various possibilites for chemical functionalization.
Nanoparticle Formation
We apply various biotechnological techniques to form micro- and nanoparticles in tunable sizes.
Biological Testing
Cellular functions and the bioactivity of the produced biomaterials are analyzed in-house with in vitro tests.
SPECIFIC PROJECTS (selection)
Examples:
“Nanoparticle Assembly of Surface-Modified Proteins” M. Fach, L. Radi, P. R. Wich
J. Am. Chem. Soc., 2016, 138 (45), 14820–14823 (DOI: 10.1021/jacs.6b06243)
“Methods of Protein Surface PEGylation under Structure Preservation for the Emulsion-based Formation of Stable Nanoparticles” L. Radi, M. Fach, M. Montigny, E. Berger-Nicoletti, W. Tremel, P. R. Wich
Med. Chem. Commun. 2016, 7, 1738–1744 (DOI: 10.1039/C5MD00475F)

Examples:
“Amphiphilic Polysaccharide Block Copolymers for pH-responsive Micellar Nanoparticles” B. Breitenbach, I. Schmid, P. R. Wich
Biomacromolecules 2017, ASAP. (DOI: 10.1021/acs.biomac.7b00771)
“Dextran-based Therapeutic Nanoparticles for Hepatic Drug Delivery” F. Foerster, D. Bamberger, J. Schupp, M. Weilbächer, L. Kaps, S. Strobl, L. Radi, M. Diken, D. Strand, A. Tuettenberg, P. R. Wich, D. Schuppan
Nanomedicine 2016, 11 (20), 2663–2677. (DOI: 10.2217/nnm-2016-0156)

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