“Protein-based Nanoparticles: From Drug Delivery to Imaging, Nanocatalysis and Protein Therapy”
J. Kaltbeitzel, P. R. Wich
Angew. Chem. Int. Ed. 2023, e202216097 (DOI: 10.1002/anie.202216097)
➞ https://onlinelibrary.wiley.com/doi/10.1002/anie.202216097

Long in the making but finally online 🎉 We summarize and highlight in this review the progress in the development of protein nanoparticles as biocompatible assemblies for a wide range of nanomedicine-related applications.

In the last decade, new generations of nanosystems emerged, that extend beyond simple transport vehicles and represent multifunctional drug delivery systems. Innovative opportunities for advanced nanomaterials include for example cell-specific interactions, catalytic active enzyme particles, or the intracellular delivery of therapeutic proteins.

Our review highlights the advantages of a broad range of underlying proteins and, in addition, has a strong focus on functional enzyme systems – a first in the context of protein nanoparticle reviews. Here we summarize recent advances for the chemical modification and formation of functional biohybrid assemblies, with resulting applications far beyond the delivery of drugs.

But wait, it gets even better! You always wanted to know, how this science would sound in German? Jonas and I also wrote a 🇩🇪 version of the paper:

“Protein-basierte Nanopartikel: Von Wirkstofftransport zu Bildgebung, Nanokatalyse und Proteintherapie”
J. Kaltbeitzel, P. R. Wich
Angew. Chem. 2023, e202216097 (DOI: 10.1002/ange.202216097)
➞ https://onlinelibrary.wiley.com/doi/10.1002/ange.202216097 

#biopolymers #proteins #enzymes #nanoparticles
#UNSW #UNSWEngineering #UNSWChemEng #WichLab #OpenAccess